Ganoderma lucidum (Reishi) induces apoptosis or cell death in leukemia, lymphoma and multiple myeloma cells                

Ganoderma lucidum (Reishi) extract was screened for its ability to stop cancer cells from multiplying using a panel of 26 human cancer cell lines. The researchers from UCLA found out that there are six hematologic cell lines that were most sensitive. Cell cycle analyses revealed a G2/M arrest, most prominently in HL-60 cells. Four hematopoietic cell lines showed cell death or apoptosis, which ranged between 21 and 92%. After exposure to G. lucidum (Reishi) extract, HL-60 cells became multinucleated with an increased DNA content. These results indicate that G. lucidum (Reishi) extract has a profound activity against leukemia, lymphoma and multiple myeloma cells and may be a novel adjunctive therapy for the treatment of hematologic malignancies.

Claudia I. Müller, Takashi Kumagai, James O’Kelly, Navindra P. Seeram, David Heber and H. Phillip Koeffler, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA.

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Ganoderma lucidum (Reishi) polysaccharides decreases blood glucose levels in Type II Diabetics    

A recent randomized and double-blind placebo-controlled clinical study has indicated that Ganoderma lucidum polysaccharides (GLP) decrease blood glucose in patients with type II diabetes. The aim of this study was to investigate the effect of the Ganoderma polysacharride extract in alloxan-induced diabetic rats. Oral administration of GLP at 0.25, 0.5 and 1.0 g/kg for 4 weeks resulted in a reduction of blood glucose levels by 12.5, 18.7 and 33.7% respectively, while glibenclamide treatment brought the hyperglycemic value down to normal. The hypoglycemic effect was supported by a significant decrease in glycosylated haemoglobin and increased plasma insulin levels (p＜0.01) in a dose- and time-dependent manner. This study showed that GLP has similar hypoglycemic effects as glibenclamide in alloxan-induced diabetic rats.

Yihuai Gao ,He Gao , Eli Chan, Wenbo Tan, Jin Lan, Hwee-Ling Koh, Guoliang Chen, Shufeng Zhou Journal of Food Science and Nutrition Vol.9 No.3, 2004. 9

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Chlorophyll helps prevent the absorption of potential cancer causing chemicals

Chlorophyll and chlorophyllin are able to form tight molecular complexes with certain chemicals known or suspected to cause cancer, including polyaromatic hydrocarbons found in tobacco smoke , some heterocyclic amines found in cooked meat , and aflatoxin-B1. The tight binding of chlorophyll or chlorophyllin to these potential carcinogens may interfere with their absorption from the gastrointestinal tract and reduce the amount that reaches susceptible tissues .

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